clinfun 1.1.0 (02/22/2022)

• Added added admissible two stage design function
• Added added futilbdry function for sequential futility stopping

clinfun (development version)

• Added a NEWS.md file to track changes to the package.
• deposited development version on GitHub
• created {pkgdown} website
• added 1:r sample allocation in gsdesign functions
• Fixed the warnings messages from deltaAUC.f

clinfun 1.0.15 (04/13/2018)

• Added new function deltaAUC to test for difference in the area under the ROC curves from nested binary regression models.
• power.ladesign does exact null if number of combinations is small
• Added to help of fedesign, ph2simon and ph2single functions

clinfun 1.0.14 (04/25/2017)

• added init.c to register native routines

clinfun 1.0.13 (11/29/2016)

• permlogrank bug fix - strata option gave an error. Names of elements in survfit.object changed. (strata instead of ntimes.strata and n a vector).

clinfun 1.0.12 (08/03/2016)

• added aucVardiTest to compare growth curves

clinfun 1.0.11 (08/11/2015)

• check for misssing values in jonckheere.test

clinfun 1.0.10 (05/18/2015)

• bug fix for pselect; nlen > 3 should have been nlen > 2

clinfun 1.0.9 (02/24/2015)

• use requireNamespace to remove NOTES on functions using survival pkg

clinfun 1.0.8 (02/19/2015)

• fix name swap in the result of mdrr in v1.0.7

clinfun 1.0.7 (02/19/2015)

• new function mdrr added to calculate minimum detectable difference in response rates for given average response rate and class proportion

clinfun 1.0.6 (06/10/2014)

• On rare occasions jonckheere.test gave a p-value bigger than 1. Sometimes 2min(iPVAL, dPVAL, 1) can be larger than 1. Replace with 2min(iPVAL, dPVAL, 0.5) (Thanks to Drs. Shterev and Owzar of Duke).

clinfun 1.0.5 (04/16/2013)

• Fixed the bound checks

clinfun 1.0.4 (01/22/2013)

• Added the option to calculate continuity corrected sample size in the function gsdesign.binomial.

clinfun 1.0.3 (10/15/2012)

• Fixed two-sided p-value > 1 bug when statistic is exactly its mean.
• Fixed Rd file to address LaTeX warnings.

clinfun 1.0.2 (09/25/2012)

• integer overflow in djonck for the Jonckheere-Terpstra statistic. replace with pdf calculation using Mark van de Wiel convolution.
• Create seperate help for functions permlogrank and jonckheere.test

clinfun 1.0.1 (08/14/2012)

• Fix integer overflow because of n0n1 == 0 in roc.curve and nnnd == 0 in roc.area.test
• In coxphQuantile eliminate times for which survival probability is 0 or 1 from quantile computation.

clinfun 1.0.0 (03/13/2012)

• clinfun number changed to 1.0.0 in preparation for R 2.15.

• toxbdry now does the entire Pocock to O’Brien-Fleming range of boundaries. Added references for the method.
• Fixed linebreak in the help for coxphERR.

clinfun 0.9.9 (01/18/2012)

• Added coxphERR to calculate Heller’s explained relative risk.
• Fixed NaN bug in toxbdry when priority=“alt” is used.

clinfun 0.9.8 (09/13/2011)

• fixed bug in print.gsdesign for binomial case (p1,p2 instead of pC,pE)
• ROC functions now check that there are at least one each of status=0,1

clinfun 0.9.7 (04/27/2011)

• fixed fortran code to address gfortran-4.6 warnings
• added ktau a faster implementation of cor(x, y, method=“k”). not in NAMESPACE. Should be called using clinfun:::ktau

clinfun 0.9.7 (04/25/2011)

• bug fix: roc.area.test integer overflow for large nn*nd.
• use sort function to speed up roc curve and area estimation.

clinfun 0.9.6 (03/24/2011)

• bug fix: roc.area.test gave NaN as the statistic and p-value when the markers are identical. Changed it to 0.

clinfun 0.9.5 (03/09/2011)

• bug fix: gsdesign funtions not returning the sample size / # events.

clinfun 0.9.4 (02/24/2011)

• twostage.inference for umvue, p-value and CI for 2 stage design.

clinfun 0.9.3 (12/06/2010)

• ph2simon was testing whether dim is null for feasible solution. Replaced with nrow == 0 since it is now possible to have 0 rows.

clinfun 0.9.2 (11/05/2010)

• Added functions to compute and plot the empirical ROC curve.

clinfun 0.9.1 (11/03/2010)

• Added functions for the area and permutation tests to compare ROC.
• Checks that min.diff is greater than 0 in pselect.

clinfun 0.9.0 (11/01/2010)

• Added a non-binding futility boundary to gsdesign

clinfun 0.8.10 (04/16/2010)

• variable names for returned data.frame in coxphQuantile
• examples in coxphQuantile & coxphCPE use status==2

clinfun 0.8.9 (04/09/2010)

• check R# clinfun so that coxphCPE works for any # clinfun (see 0.8.9)

clinfun 0.8.8 (04/07/2010)

• Change coxphCPE to reflect the fact that model.matrix.coxph doesn’t have an intercept term.

clinfun 0.8.8 (02/25/2010)

• Added the function or2pcase

clinfun 0.8.7 (11/20/2009)

• Fixed the 0/0 bug in the revised pselect

clinfun 0.8.6 (11/17/2009)

• Changed Venkat’s affiliation to MSKCC.
• Fixed pselect to calculate the selection probability correctly when only one treatment exceeds the min.resp threshold.

clinfun 0.8.5 (07/10/2009)

• Changed the Jonckheere-Terpstra statistic such that large value is indicative of increasing group locations and small for decreasing. Function warns that p-value is based on approximation for tied data.

clinfun 0.8.4 (12/02/2008)

• Added functionality to pselect. It can do unequal sample size for the case of two treatments. min.diff can be specified as a rate instead of number of responses. Output element names changed to be more descriptive.

clinfun 0.8.3 (11/18/2008 & 09/18/2008)

• Fixed the bug CPS.ssize. call inside used fixed alpha, power & r.
• Fixed the bug in the approximate one-sided p-value of Jonckheere test. wrong tail was used.

clinfun 0.8.2 (06/20/2008)

• toxbdry allows the error threshold to prioritize when the sample size is too small to have both satisfied.

clinfun 0.8.1 (06/17/2008)

• Fixed gsdesign to allow for fixed sample designs. Help file fixed.

clinfun 0.8.0 (05/23/2008)

• New # clinfun with one new function power.lehmann.design