ToxCrit: Calculates Safety Stopping Boundaries for a Single-Arm Trial
using Bayes
Computation of stopping boundaries for a single-arm trial using a
Bayesian criterion; i.e., for each m<=n (n= total patient number of the
trial) the smallest number of observed toxicities is calculated
leading to the termination of the trial/accrual according to the specified
criteria. The probabilities of stopping the trial/accrual at and up until
(resp.) the m-th patient (m<=n) is also calculated. This design is more
conservative than the frequentist approach (using Clopper Pearson CIs)
which might be preferred as it concerns safety.See also Aamot et.al.(2010)
"Continuous monitoring of toxicity in clinical trials - simulating the risk
of stopping prematurely" <doi:10.5414/cpp48476>.
| Version: |
1.0 |
| Published: |
2021-10-01 |
| Author: |
NCT Trial Center, Heidelberg [aut],
Lisa-Marie Lanz [cre] |
| Maintainer: |
Lisa-Marie Lanz <studienzentrale at nct-heidelberg.de> |
| License: |
GPL-3 |
| NeedsCompilation: |
no |
| Language: |
en-US |
| Materials: |
README NEWS |
| CRAN checks: |
ToxCrit results |
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